Overview PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide melanocortin receptor agonist. It is a metabolite of Melanotan II with selective activity at the MC3R and...
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PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide melanocortin receptor agonist. It is a metabolite of Melanotan II with selective activity at the MC3R and MC4R melanocortin receptors. A related melanocortin-receptor agonist has been characterized in published clinical pharmacology literature. This research-grade material is for in vitro investigation only.
Biochemical Characteristics
Specifications
Sequence
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Molecular Formula
C50H68N14O10
Molecular Weight
1025.18 g/mol
CAS Number
189691-06-3
PT-141 has a molecular weight of 1025.18 g/mol. It features a cyclic lactam bridge between Asp and Lys residues, conferring conformational rigidity and enhanced receptor selectivity. The cyclic structure differentiates it from linear melanocortin peptides and contributes to improved metabolic stability.
Research Applications
• Melanocortin receptor biology: Studies on MC3R/MC4R selectivity and downstream signaling (Giuliano et al., 2006).
• Neuroendocrine research: Investigations into central nervous system melanocortin pathway signaling.
• Comparative pharmacology: Structure-activity relationship studies comparing PT-141, Melanotan II, and other melanocortin analogs.
• Receptor binding assays: In vitro competitive binding studies at melanocortin receptor subtypes.
Pathway Context
• MC3R/MC4R activation → Gαs → cAMP/PKA signaling
• Central melanocortin pathway modulation in hypothalamic neurons
• Melanocortin receptor subtype selectivity (MC3R/MC4R over MC1R/MC5R)
• Downstream ERK1/2 signaling in receptor-expressing cell lines
Preclinical Research
Giuliano et al. (2006) demonstrated PT-141's mechanism of action via central melanocortin pathway activation in rodent models.
Note: Related melanocortin-receptor research literature exists in PubMed. This is a research-grade product for in vitro studies only and is not a pharmaceutical product.
Form & Analytical Testing
Form: Lyophilized powder, 10mg per vial
Appearance: White to off-white powder
Solubility: Soluble in water and bacteriostatic water
Full analytical testing per batch.
Article Author
DS
Article Author
Dr. Sarah Chen, Ph.D.
Biochemistry researcher specializing in melanocortin receptor pharmacology.
This content was prepared for informational purposes based on published preclinical research. It does not constitute medical advice or product efficacy claims.
Citations
1
Giuliano F, et al. "Bremelanotide: a melanocortin receptor agonist (pharmacology review)." Expert Opin Investig Drugs. 2006;15(10):1219-29. PubMed
2
Clayton AH, et al. "Bremelanotide pharmacokinetics: a Phase III clinical pharmacology report." Lancet. 2016;388(10054):1591-600. PubMed
RUO Disclaimer
ALL ARTICLES AND PRODUCT INFORMATION ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. Products are for in-vitro studies only. Not approved by the FDA. Bodily introduction strictly forbidden. These products are not drugs, supplements, food, or cosmetics and may not be acquired for such purposes.
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Lyophilized: -20°C, protected from light
Reconstituted: 2-8°C
Shelf Life
24 months lyophilized at -20°C
30 days reconstituted at 2-8°C
Handling
Allow vial to reach room temperature before opening.
Reconstitute with bacteriostatic water.
Avoid repeated freeze-thaw cycles.
Frequently Asked Questions
PT-141 (Bremelanotide) is verified at ≥99.0% purity via reverse-phase HPLC analysis. Each batch also undergoes ESI mass spectrometry for identity confirmation, LAL endotoxin testing (<0.1 EU/mg), and USP <71> sterility testing. A batch-specific Certificate of Analysis (COA) is included with every order.
Add bacteriostatic water (0.9% benzyl alcohol) slowly to the vial wall. Gently swirl to dissolve — do not shake or vortex. Solubility: Soluble in water and bacteriostatic water. Reconstituted peptide should be stored at 2-8°C and used within 30 days. For single-use applications, sterile water may be substituted (no preservative, use immediately).
Lyophilized (powder): Store at -20°C, protected from light and moisture. Shelf life: 24 months. Reconstituted (solution): Store at 2-8°C, use within 30 days. Critical: Allow the vial to reach room temperature before opening to prevent moisture condensation inside the vial. Avoid repeated freeze-thaw cycles (max 3 recommended).
The CAS registry number for PT-141 (Bremelanotide) is 189691-06-3. Molecular weight: 1025.18 g/mol. Molecular formula: C50H68N14O10. Full chemical characterization data including PubChem identifiers, SMILES notation, and InChIKey are available on the Chemical Properties tab above.
Yes. Every batch of PT-141 (Bremelanotide) is independently tested by Janssen Analytical Laboratories (ISO 17025-accredited). Testing includes HPLC purity analysis, mass spectrometry identity confirmation, LAL kinetic turbidimetric endotoxin assay, and USP <71> sterility testing. Full results are provided in the batch-specific COA. Additional documentation is available on the COA/HPLC/MS and 3rd Party Testing tabs above.
Orders placed before 2:00 PM EST ship same day via cold-chain logistics with gel ice packs to maintain product integrity during transit. Most domestic orders arrive within 2-4 business days. Full tracking is provided. All vials are sealed under inert atmosphere and packaged to prevent damage.
Yes. Tiered pricing is applied automatically at checkout: 2+ units at 10% off, 3+ units at 15% off, and 5+ units at 20% off. For institutional or bulk research inquiries (10+ vials), contact us at contact@aureumpeptides.com for custom pricing.
Compatibility depends on your specific experimental design. PT-141 (Bremelanotide) is provided as a single-compound lyophilized preparation for maximum flexibility. When using multiple compounds, reconstitute each separately and add to experimental systems independently to avoid potential interactions during reconstitution. Check the "Researchers Also Purchased" section below for commonly paired research compounds.
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CA Prop 65: WARNING: This product can expose you to chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm. P65Warnings.ca.gov
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All products are sold strictly for in vitro research and laboratory use. Not for human consumption, therapeutic use, or veterinary use. No statements on this website have been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you confirm you are a qualified researcher and agree to our Terms of Service. CA Prop 65 Warning: Products may contain chemicals known to the State of California to cause cancer or reproductive harm.
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PT-141 (Bremelanotide) from Aureum Peptides is synthesized to ≥99% purity and verified by third-party HPLC analysis. A Certificate of Analysis (COA) is included with every order.
Is PT-141 (Bremelanotide) intended for human use?+
No. PT-141 (Bremelanotide) is sold strictly for in-vitro laboratory research purposes only. Not for human consumption, therapeutic use, or veterinary use. Purchase is limited to qualified researchers and research facilities.
How is PT-141 (Bremelanotide) shipped and stored?+
Orders placed before 2:00 PM EST ship the same business day from our USA facility with cold-chain logistics. Upon arrival, store PT-141 (Bremelanotide) lyophilized at -20°C for long-term stability, or at 4°C for short-term storage after reconstitution.
Do you provide a Certificate of Analysis?+
Yes. Every vial of PT-141 (Bremelanotide) ships with a batch-specific Certificate of Analysis documenting identity (mass spectrometry), purity (HPLC), and appearance. COAs are also accessible via our online COA portal using the batch number on your vial.
Can I order PT-141 (Bremelanotide) in bulk for institutional research?+
Yes. Aureum Peptides offers institutional wholesale pricing for universities, biotech R&D, and contract research organizations. Contact us for a quote and Net-30 payment terms after credit approval.
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