GHK-Cu
Copper-binding tripeptide (Gly-His-Lys-Cu²⁺). ≥99% purity. 5mg lyophilized. Studied for gene expression modulation and collagen synthesis in dermatological research.
Overview
GHK-Cu (Copper Tripeptide-1) is a naturally occurring tripeptide-copper complex found in human plasma. First identified in human plasma in 1973 by Dr. Loren Pickart. Research spans over 4,000 human genes.
Published Research
Published literature has examined GHK-Cu across multiple research contexts:
- Interaction with over 4,000 human genes including those associated with collagen synthesis
- Extracellular matrix remodeling and metalloproteinase regulation
- Antioxidant enzyme production pathways (SOD, catalase)
- Dermal tissue research including fibroblast activity and copper ion delivery
| Molecular Formula | C14H23CuN6O4 |
|---|---|
| Molecular Weight | 403.92 g/mol |
| Monoisotopic Mass | 402.11 Da |
| CAS Number | 130120-56-8 |
| Amino Acid Count | 3 |
| Sequence | Gly-His-Lys (complexed with Cu²⁺) |
| Purity | ≥99.3% (HPLC verified) |
| Physical Form | White lyophilized powder |
| Storage | -20°C recommended, protect from light |
| PubChem CID | 9831891 |
| SKU | GHKCU-200MG |
• Dermatological research: Studies have examined GHK-Cu's effects on collagen synthesis, glycosaminoglycan production, and dermal fibroblast proliferation in cell culture models (Pickart et al., 2012).
• Gene expression: Connectivity Map analysis identified GHK as modulating expression of 4,000+ human genes, with emphasis on genes associated with tissue remodeling and antioxidant defense (Campbell et al., 2012).
• Wound biology: Preclinical studies have investigated copper peptide effects on wound contraction and re-epithelialization rates.
• Antioxidant research: Studies have examined GHK-Cu's interaction with superoxide dismutase activity and free radical quenching.
Standard reconstitution: 1 mL bacteriostatic water per vial unless otherwise specified on the Certificate of Analysis. Store reconstituted solution at 2-8°C and use within 30 days. Lyophilized powder stable at -20°C for 24 months when sealed under inert atmosphere.
Every lot ships with a third-party HPLC certificate. View the most recent lot certificate via the COA Portal. Mass spectrometry confirmation available on request.
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