Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH) fragment 4-7 with a Pro-Gly-Pro C-terminal extension. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax has been studied for its neurotrophic and nootropic properties. It is registered as a pharmaceutical in Russia for cognitive and neurological research applications.
Biochemical Characteristics
Specifications
Sequence
Met-Glu-His-Phe-Pro-Gly-Pro
Molecular Formula
C37H51N9O10
Molecular Weight
813.93 g/mol
CAS Number
80714-61-0
Semax has a molecular weight of 813.93 g/mol. The ACTH(4-7) core sequence (Met-Glu-His-Phe) is responsible for the melanocortin-like activity, while the Pro-Gly-Pro extension enhances metabolic stability and biological half-life by conferring resistance to peptidases.
Research Applications
• Neurotrophic factor research: Studies have examined Semax effects on BDNF, NGF, and GDNF expression in neuronal cell cultures (Dolotov et al., 2006).
• Cognitive biology: Animal behavioral studies using Morris water maze and passive avoidance paradigms.
• Neuroprotection: Research in models of oxidative stress and ischemia-reperfusion in neuronal systems.
• Immune modulation: Studies examining effects on cytokine profiles and immune cell function.
Dolotov et al. (2006): Semax at 100 µg/kg increased BDNF mRNA expression 2.8-fold and NGF mRNA 1.5-fold in rat hippocampus within 3 hours of administration. Effects persisted for 24 hours.
Agapova et al. (2007): Microarray analysis revealed Semax modulated expression of 24 genes in rat brain, including upregulation of neurotrophins (BDNF, GDNF), immediate early genes (c-fos), and neuroprotective factors.
Levitskaya et al. (2004): Semax at 50-600 µg/kg improved cognitive performance in passive avoidance and Morris water maze tasks in rodents. Optimal dose: 100 µg/kg.
Typical in vitro concentrations: 0.1-100 µM. In vivo: 50-600 µg/kg.
Semax is registered as a pharmaceutical in Russia (approved 2011) but has not undergone FDA review.
Form & Analytical Testing
Form: Lyophilized powder, 5mg per vial
Appearance: White powder
Molecular Weight: 813.93 g/mol
For In Vitro Research Use Only
This product is for laboratory and in vitro research only. Not for human or animal use.
Article Author
DS
Article Author
Dr. Sarah Chen, Ph.D.
Biochemistry researcher specializing in neuropeptide characterization.
This content was prepared for informational purposes based on published preclinical research. It does not constitute medical advice or product efficacy claims.
Citations
1
Dolotov OV, et al. "Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus." Brain Res. 2006;1117(1):54-60. PubMed: 16942753PubMed
2
Agapova TY, et al. "Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus." Mol Biol. 2008;42(1):30-5. PubMed
3
Levitskaya NG, et al. "The neuroprotective effects of Semax in conditions of MPTP-induced lesion of dopaminergic brain system." Neurosci Behav Physiol. 2004;34(4):399-404. PubMed
RUO Disclaimer
ALL ARTICLES AND PRODUCT INFORMATION ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. Products are for in-vitro studies only. Not approved by the FDA. Bodily introduction strictly forbidden. These products are not drugs, supplements, food, or cosmetics and may not be acquired for such purposes.
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Lyophilized: -20°C, protected from light
Reconstituted: 2-8°C
Shelf Life
24 months lyophilized at -20°C
30 days reconstituted at 2-8°C
Handling
Allow vial to reach room temperature before opening.
Reconstitute with bacteriostatic water.
Avoid repeated freeze-thaw cycles.
Contains methionine; minimize oxidative exposure.
Frequently Asked Questions
Semax is verified at ≥99.2% purity via reverse-phase HPLC analysis. Each batch also undergoes ESI mass spectrometry for identity confirmation, LAL endotoxin testing (<0.1 EU/mg), and USP <71> sterility testing. A batch-specific Certificate of Analysis (COA) is included with every order.
Add bacteriostatic water (0.9% benzyl alcohol) slowly to the vial wall. Gently swirl to dissolve — do not shake or vortex. Reconstituted peptide should be stored at 2-8°C and used within 30 days. For single-use applications, sterile water may be substituted (no preservative, use immediately).
Lyophilized (powder): Store at -20°C, protected from light and moisture. Shelf life: 24 months. Reconstituted (solution): Store at 2-8°C, use within 30 days. Critical: Allow the vial to reach room temperature before opening to prevent moisture condensation inside the vial. Avoid repeated freeze-thaw cycles (max 3 recommended).
The CAS registry number for Semax is 80714-61-0. Molecular weight: 813.93 g/mol. Molecular formula: C37H51N9O10. Full chemical characterization data including PubChem identifiers, SMILES notation, and InChIKey are available on the Chemical Properties tab above.
Yes. Every batch of Semax is independently tested by Janssen Analytical Laboratories (ISO 17025-accredited). Testing includes HPLC purity analysis, mass spectrometry identity confirmation, LAL kinetic turbidimetric endotoxin assay, and USP <71> sterility testing. Full results are provided in the batch-specific COA. Additional documentation is available on the COA/HPLC/MS and 3rd Party Testing tabs above.
Orders placed before 2:00 PM EST ship same day via cold-chain logistics with gel ice packs to maintain product integrity during transit. Most domestic orders arrive within 2-4 business days. Full tracking is provided. All vials are sealed under inert atmosphere and packaged to prevent damage.
Yes. Tiered pricing is applied automatically at checkout: 2+ units at 10% off, 3+ units at 15% off, and 5+ units at 20% off. For institutional or bulk research inquiries (10+ vials), contact us at contact@aureumpeptides.com for custom pricing.
Compatibility depends on your specific experimental design. Semax is provided as a single-compound lyophilized preparation for maximum flexibility. When using multiple compounds, reconstitute each separately and add to experimental systems independently to avoid potential interactions during reconstitution. Check the "Researchers Also Purchased" section below for commonly paired research compounds.
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Semax from Aureum Peptides is synthesized to ≥99% purity and verified by third-party HPLC analysis. A Certificate of Analysis (COA) is included with every order.
Is Semax intended for human use?+
No. Semax is sold strictly for in-vitro laboratory research purposes only. Not for human consumption, therapeutic use, or veterinary use. Purchase is limited to qualified researchers and research facilities.
How is Semax shipped and stored?+
Orders placed before 2:00 PM EST ship the same business day from our USA facility with cold-chain logistics. Upon arrival, store Semax lyophilized at -20°C for long-term stability, or at 4°C for short-term storage after reconstitution.
Do you provide a Certificate of Analysis?+
Yes. Every vial of Semax ships with a batch-specific Certificate of Analysis documenting identity (mass spectrometry), purity (HPLC), and appearance. COAs are also accessible via our online COA portal using the batch number on your vial.
Can I order Semax in bulk for institutional research?+
Yes. Aureum Peptides offers institutional wholesale pricing for universities, biotech R&D, and contract research organizations. Contact us for a quote and Net-30 payment terms after credit approval.
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