MOTS-C
Mitochondrial-derived peptide (16 amino acids). ≥99% purity. 5mg lyophilized. Studied for AMPK pathway activation and metabolic regulation in preclinical models.
Overview
MOTS-C (Mitochondrial ORF of 12S rRNA Type C) is a mitochondrial-derived peptide encoded by mitochondrial DNA. Discovered in 2015 by Dr. Changhan Lee at USC Leonard Davis School of Gerontology.
Published Research
Published literature has examined MOTS-C across multiple research contexts:
- AMPK pathway activation and metabolic sensor modulation
- Glucose metabolism and insulin sensitivity research in preclinical models
- Exercise physiology - circulating MOTS-C levels increase with physical activity
- Mitochondrial-nuclear communication (retrograde signaling) research
| Molecular Formula | C101H152N28O23S2 |
|---|---|
| Molecular Weight | 2174.64 g/mol |
| Monoisotopic Mass | 2173.1 Da |
| CAS Number | 1627580-64-6 |
| Amino Acid Count | 16 |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| Purity | ≥99.0% (HPLC verified) |
| Physical Form | White lyophilized powder |
| Storage | -20°C recommended, protect from light |
| PubChem CID | 146675088 |
| SKU | MOTSC-10MG |
• Metabolic biology: MOTS-c has been studied for its effects on glucose metabolism and insulin sensitivity in murine models of diet-induced obesity (Lee et al., 2015).
• AMPK pathway: Research has examined MOTS-c's interaction with AMP-activated protein kinase signaling in metabolic regulation.
• Exercise biology: Studies have investigated MOTS-c as an exercise-mimetic peptide, examining skeletal muscle metabolism effects.
• Aging research: Investigations into MOTS-c levels across age groups and its potential role in age-related metabolic changes.
Standard reconstitution: 1 mL bacteriostatic water per vial unless otherwise specified on the Certificate of Analysis. Store reconstituted solution at 2-8°C and use within 30 days. Lyophilized powder stable at -20°C for 24 months when sealed under inert atmosphere.
Every lot ships with a third-party HPLC certificate. View the most recent lot certificate via the COA Portal. Mass spectrometry confirmation available on request.
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