Selank is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro extension. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, it has been studied for both anxiolytic and immunomodulatory properties in preclinical and early clinical research.
Biochemical Characteristics
Specifications
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Molecular Formula
C33H57N11O9
Molecular Weight
751.87 g/mol
CAS Number
129954-34-3
Selank has a molecular weight of 751.87 g/mol. The tuftsin core (residues 1-4) is a natural tetrapeptide derived from the Fc region of IgG that has known immunostimulatory activity. The Pro-Gly-Pro extension enhances metabolic stability and extends biological half-life.
Research Applications
• Anxiolytic research: Studies examining Selank effects in elevated plus-maze and Vogel conflict test paradigms in rodents.
• Immunomodulation: Research on Selank's effects on IL-6, IFN-gamma, and other cytokine expression profiles.
• Gene expression: Microarray studies examining Selank's effects on gene expression in hippocampal tissue.
• Enkephalin metabolism: Studies on Selank's interaction with enkephalin degradation pathways.
Pathway Context
• GABA-A receptor system interaction
• Enkephalinase inhibition and endogenous opioid modulation
• IL-6 and TNF-alpha expression regulation
• Monoamine system interaction (serotonin, dopamine)
• BDNF expression modulation
Preclinical Research
Seredenin et al. (2009) demonstrated anxiolytic-like effects of Selank in multiple rodent behavioral models without sedation or motor impairment.
Uchakina et al. (2008) showed Selank modulated cytokine expression profiles in human peripheral blood mononuclear cells.
Selank has been registered as a pharmaceutical in Russia since 2009.
Form & Analytical Testing
Form: Lyophilized powder, 5mg per vial
Appearance: White powder
Molecular Weight: 751.87 g/mol
Reconstitution Guide:
- For 1 mg/mL: Add 5.0 mL bacteriostatic water
- For 5 mg/mL: Add 1.0 mL bacteriostatic water
- Dissolves readily; gently swirl
Solubility: Freely soluble in water (>20 mg/mL), bacteriostatic water, PBS, saline.
Stability: Lyophilized stable 24 months at -20°C. Reconstituted: 30 days at 2-8°C. Pro-Gly-Pro extension confers enhanced protease resistance vs native tuftsin.
Note: The Pro-Gly-Pro C-terminal extension was specifically engineered to resist degradation by carboxypeptidases and endopeptidases, extending the biological half-life 3-5x compared to native tuftsin (Thr-Lys-Pro-Arg).
Biochemistry researcher specializing in neuropeptide and immunopeptide characterization.
This content was prepared for informational purposes based on published preclinical research. It does not constitute medical advice or product efficacy claims.
Citations
1
Seredenin SB, et al. "Anxiolytic-like effect of selank in comparison with nozepam." Bull Exp Biol Med. 2009;148(1):80-3. PubMed
2
Uchakina ON, et al. "Immunomodulatory effects of selank in patients with anxiety-asthenic disorders." Bull Exp Biol Med. 2008;146(3):353-5. PubMed
3
Kozlovskii II, Danchev ND. "Optimizing effect of selank on the conditioned reflex activity of rats." Bull Exp Biol Med. 2003;135(6):514-6. PubMed: 12937666PubMed
RUO Disclaimer
ALL ARTICLES AND PRODUCT INFORMATION ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. Products are for in-vitro studies only. Not approved by the FDA. Bodily introduction strictly forbidden. These products are not drugs, supplements, food, or cosmetics and may not be acquired for such purposes.
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Lyophilized: -20°C, protected from light
Reconstituted: 2-8°C
Shelf Life
24 months lyophilized at -20°C
30 days reconstituted at 2-8°C
Handling
Allow vial to reach room temperature before opening.
Reconstitute with bacteriostatic water.
Avoid repeated freeze-thaw cycles.
Frequently Asked Questions
Selank is verified at ≥99.1% purity via reverse-phase HPLC analysis. Each batch also undergoes ESI mass spectrometry for identity confirmation, LAL endotoxin testing (<0.1 EU/mg), and USP <71> sterility testing. A batch-specific Certificate of Analysis (COA) is included with every order.
Add bacteriostatic water (0.9% benzyl alcohol) slowly to the vial wall. Gently swirl to dissolve — do not shake or vortex. Solubility: Freely soluble in water (>20 mg/mL), bacteriostatic water, PBS, saline.. Reconstituted peptide should be stored at 2-8°C and used within 30 days. For single-use applications, sterile water may be substituted (no preservative, use immediately).
Lyophilized (powder): Store at -20°C, protected from light and moisture. Shelf life: 24 months. Reconstituted (solution): Store at 2-8°C, use within 30 days. Critical: Allow the vial to reach room temperature before opening to prevent moisture condensation inside the vial. Avoid repeated freeze-thaw cycles (max 3 recommended).
The CAS registry number for Selank is 129954-34-3. Molecular weight: 751.87 g/mol. Molecular formula: C33H57N11O9. Full chemical characterization data including PubChem identifiers, SMILES notation, and InChIKey are available on the Chemical Properties tab above.
Yes. Every batch of Selank is independently tested by Janssen Analytical Laboratories (ISO 17025-accredited). Testing includes HPLC purity analysis, mass spectrometry identity confirmation, LAL kinetic turbidimetric endotoxin assay, and USP <71> sterility testing. Full results are provided in the batch-specific COA. Additional documentation is available on the COA/HPLC/MS and 3rd Party Testing tabs above.
Orders placed before 2:00 PM EST ship same day via cold-chain logistics with gel ice packs to maintain product integrity during transit. Most domestic orders arrive within 2-4 business days. Full tracking is provided. All vials are sealed under inert atmosphere and packaged to prevent damage.
Yes. Tiered pricing is applied automatically at checkout: 2+ units at 10% off, 3+ units at 15% off, and 5+ units at 20% off. For institutional or bulk research inquiries (10+ vials), contact us at contact@aureumpeptides.com for custom pricing.
Compatibility depends on your specific experimental design. Selank is provided as a single-compound lyophilized preparation for maximum flexibility. When using multiple compounds, reconstitute each separately and add to experimental systems independently to avoid potential interactions during reconstitution. Check the "Researchers Also Purchased" section below for commonly paired research compounds.
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CA Prop 65: WARNING: This product can expose you to chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm. P65Warnings.ca.gov
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