Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) developed by Novo Nordisk. It is a selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS-R1a) and is notable for its selectivity in stimulating GH release without significantly affecting cortisol, prolactin, or ACTH levels in preclinical studies.
Biochemical Characteristics
Specifications
Sequence
Aib-His-D-2-Nal-D-Phe-Lys-NH2
Molecular Formula
C38H49N9O5
Molecular Weight
711.85 g/mol
CAS Number
170851-70-4
Ipamorelin has a molecular weight of 711.85 g/mol and contains non-standard amino acids (Aib and D-2-naphthylalanine) that confer enhanced receptor selectivity and metabolic stability. Its pentapeptide structure allows selective GHS-R1a binding without the broader endocrine effects seen with earlier secretagogues.
The C-terminal amidation (-NH2) improves receptor binding affinity and resistance to carboxypeptidase degradation.
Research Applications
• GH secretagogue biology: Studies have examined Ipamorelin's selective GHS-R1a activation and its specificity for GH release over other pituitary hormones (Raun et al., 1998).
• Bone biology: Preclinical studies have investigated Ipamorelin's effects on bone mineral density and osteoblast activity in ovariectomized rat models.
• GI motility: Research has examined ghrelin receptor-mediated effects on gastrointestinal transit in animal models.
• Neuroendocrine selectivity: Comparative studies examining Ipamorelin's endocrine profile versus GHRP-6 and GHRP-2.
Pathway Context
• GHS-R1a receptor activation → IP3/DAG signaling
• Selective somatotroph GH release without ACTH or cortisol stimulation
• Synergistic interaction with GHRH pathway for enhanced GH pulsatility
• Ghrelin-like vagal afferent signaling in GI motility models
Preclinical Research
Key preclinical findings:
Raun et al. (1998): Ipamorelin at 0.1 mg/kg was equipotent to GHRP-6 for GH release in swine but did NOT stimulate ACTH or cortisol at any dose tested (up to 1 mg/kg). This selectivity distinguishes it from earlier secretagogues.
Hansen et al. (1999): In human pharmacological studies, Ipamorelin showed dose-dependent GH release (0.03-0.3 mg/kg IV) without affecting cortisol, prolactin, FSH, LH, or TSH levels.
Johansen et al. (1999): Ipamorelin at 0.1 mg/kg stimulated GH release in rodents with similar amplitude to GHRP-6 but narrower pituitary hormone profile (GH only).
EC50 for GH release: ~3-10 nM at GHS-R1a receptor.
All findings from preclinical and early clinical studies.
Form & Analytical Testing
Form: Lyophilized powder, 5mg per vial
Appearance: White powder
Molecular Weight: 711.85 g/mol
Reconstitution Guide:
- For 1 mg/mL: Add 5.0 mL bacteriostatic water
- For 2 mg/mL: Add 2.5 mL bacteriostatic water
- Gently swirl until dissolved
Solubility: Soluble in water (~5-10 mg/mL), bacteriostatic water, PBS. Slightly soluble in ethanol.
Stability: Lyophilized stable 24 months at -20°C. Reconstituted: 30 days at 2-8°C.
Analytical Testing: HPLC, ESI-MS, LAL endotoxin, USP sterility. COA per batch.
Article Author
DS
Article Author
Dr. Sarah Chen, Ph.D.
Biochemistry researcher specializing in neuroendocrine peptide pharmacology.
This content was prepared for informational purposes based on published preclinical research. It does not constitute medical advice or product efficacy claims.
Citations
1
Raun K, et al. "Ipamorelin, the first selective growth hormone secretagogue." Eur J Endocrinol. 1998;139(5):552-61. PubMed: 9849822PubMed
2
Hansen BS, et al. "The pharmacology of ipamorelin." Growth Horm IGF Res. 1999;9 Suppl A:60-3. PubMed
3
Johansen PB, et al. "Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats." Growth Horm IGF Res. 1999;9(2):106-13. PubMed: 10373343PubMed
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ALL ARTICLES AND PRODUCT INFORMATION ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. Products are for in-vitro studies only. Not approved by the FDA. Bodily introduction strictly forbidden. These products are not drugs, supplements, food, or cosmetics and may not be acquired for such purposes.
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Lyophilized: -20°C, protected from light
Reconstituted: 2-8°C
Shelf Life
24 months lyophilized at -20°C
30 days reconstituted at 2-8°C
Handling
Allow vial to reach room temperature before opening.
Reconstitute with bacteriostatic water.
Avoid repeated freeze-thaw cycles.
Frequently Asked Questions
Ipamorelin is verified at ≥99.3% purity via reverse-phase HPLC analysis. Each batch also undergoes ESI mass spectrometry for identity confirmation, LAL endotoxin testing (<0.1 EU/mg), and USP <71> sterility testing. A batch-specific Certificate of Analysis (COA) is included with every order.
Add bacteriostatic water (0.9% benzyl alcohol) slowly to the vial wall. Gently swirl to dissolve — do not shake or vortex. Solubility: Soluble in water (~5-10 mg/mL), bacteriostatic water, PBS. Slightly soluble in ethanol.. Reconstituted peptide should be stored at 2-8°C and used within 30 days. For single-use applications, sterile water may be substituted (no preservative, use immediately).
Lyophilized (powder): Store at -20°C, protected from light and moisture. Shelf life: 24 months. Reconstituted (solution): Store at 2-8°C, use within 30 days. Critical: Allow the vial to reach room temperature before opening to prevent moisture condensation inside the vial. Avoid repeated freeze-thaw cycles (max 3 recommended).
The CAS registry number for Ipamorelin is 170851-70-4. Molecular weight: 711.85 g/mol. Molecular formula: C38H49N9O5. Full chemical characterization data including PubChem identifiers, SMILES notation, and InChIKey are available on the Chemical Properties tab above.
Yes. Every batch of Ipamorelin is independently tested by Janssen Analytical Laboratories (ISO 17025-accredited). Testing includes HPLC purity analysis, mass spectrometry identity confirmation, LAL kinetic turbidimetric endotoxin assay, and USP <71> sterility testing. Full results are provided in the batch-specific COA. Additional documentation is available on the COA/HPLC/MS and 3rd Party Testing tabs above.
Orders placed before 2:00 PM EST ship same day via cold-chain logistics with gel ice packs to maintain product integrity during transit. Most domestic orders arrive within 2-4 business days. Full tracking is provided. All vials are sealed under inert atmosphere and packaged to prevent damage.
Yes. Tiered pricing is applied automatically at checkout: 2+ units at 10% off, 3+ units at 15% off, and 5+ units at 20% off. For institutional or bulk research inquiries (10+ vials), contact us at contact@aureumpeptides.com for custom pricing.
Compatibility depends on your specific experimental design. Ipamorelin is provided as a single-compound lyophilized preparation for maximum flexibility. When using multiple compounds, reconstitute each separately and add to experimental systems independently to avoid potential interactions during reconstitution. Check the "Researchers Also Purchased" section below for commonly paired research compounds.
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