What is the purity of Sermorelin?

Sermorelin is verified at ≥99.0% purity via HPLC analysis. A Certificate of Analysis (COA) with full chromatogram is included with every order.

How should I store Sermorelin?

Lyophilized: Store at -20°C, protected from light and moisture (24-month shelf life). Reconstituted: Store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles.

What is included with my Sermorelin order?

Each order includes the lyophilized compound in a sealed vial, a batch-specific Certificate of Analysis (COA), and cold-chain shipping to maintain product integrity during transit.

Does Sermorelin come with a Certificate of Analysis?

Yes. Every batch is independently tested by ISO 17025-accredited laboratories. The COA includes HPLC purity data, mass spectrometry identity confirmation, endotoxin testing, and sterility results.

How quickly will my order ship?

Orders placed before 2:00 PM EST ship same day via cold-chain logistics. Most domestic orders arrive within 2-4 business days with full tracking provided.

What is the CAS number for Sermorelin?

The CAS registry number for Sermorelin is 86168-78-7. This compound is available for legitimate in vitro research purposes only.

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SOMATOTROPIC RESEARCH

Sermorelin

Name: Sermorelin
Brand: Aureum Peptides
SKU: SERM
Price: 30 USD
Availability: InStock

GRF 1-29, GHRH(1-29)NH2, Geref

Sequence

29 AA

Mol. Weight

3357.88

CAS

86168-78-7

Purity

99.0

99.0 Purity

COA Included

Same-Day Dispatch

Native GHRH(1-29) fragment (29 amino acids). ≥99% purity. 2mg lyophilized. Previously investigational diagnostic agent. GHRH receptor agonist for neuroendocrine research.

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Estimated delivery: Jun 4 - Jun 6

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For Research Purposes Only • Not For Human Consumption

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This product is intended strictly for in vitro research and laboratory use by qualified researchers. It is not a drug, food, or cosmetic. Aureum Peptides makes no claims regarding safety or efficacy for any purpose. By purchasing, you agree to the Research Use Agreement.

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SKU: SERM

Category: Somatotropic Research

Research Catalog — N° SERM

Ships Tuesday, Jun 2
Estimated delivery: Jun 4 – Jun 9

Certificate of Analysis

99.0%+ purity HPLC verified Third-party tested

View batch-specific COA

📦 Ships next business day
Standard delivery: Jun 5 – Jun 9 | Express: Jun 3 – Jun 4

✓ Free shipping on orders $200+✓ Ships same day before 2PM EST✓ Temperature-controlled packaging available

Quality & Transparency

Every batch tested. Every result published. No exceptions.

Verified Purity %

Janssen Analytical Laboratories

Testing Partner

#SER-2026-04

Current Batch

View Full COA

1.Overview

2.Biochemical Characteristics

3.Research Applications

4.Pathway Context

5.Preclinical Research

6.Form & Analytical Testing

7.Article Author

8.Citations

9.RUO Disclaimer

Overview

Sermorelin (GRF 1-29) is a synthetic 29-amino acid peptide corresponding to the first 29 amino acids of naturally occurring human growth hormone-releasing hormone (GHRH). It was previously approved by the FDA as Geref for diagnostic evaluation of pituitary function. Sermorelin acts as a GHRH receptor agonist to stimulate physiological GH release from the anterior pituitary.

Biochemical Characteristics

Specifications

Sequence

Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2

Molecular Formula

C149H246N44O42S

Molecular Weight

3357.88 g/mol

CAS Number

86168-78-7

Sermorelin has a molecular weight of 3357.88 g/mol. It represents the biologically active N-terminal fragment of the 44-amino acid native GHRH. The first 29 residues contain the full receptor-binding domain required for GHRHR activation.

The C-terminal amidation improves stability and receptor affinity compared to the free acid form.

Research Applications

• Neuroendocrine research: Sermorelin has been used as a diagnostic tool for pituitary GH reserve assessment in clinical settings.
• GH axis biology: Studies have examined pulsatile GH release patterns and somatotroph responsiveness to GHRH stimulation.
• Aging research: Investigations into age-related changes in GHRH responsiveness and GH-IGF-1 axis function.
• Metabolic research: Studies on GH-mediated effects on body composition and metabolism.

Pathway Context

• GHRHR binding → Gs protein → adenylyl cyclase → cAMP/PKA cascade
• Somatotroph intracellular calcium mobilization and GH vesicle exocytosis
• Physiological GH pulsatility maintenance
• Hypothalamic-pituitary feedback regulation with somatostatin

Preclinical Research

Gelander et al. (2012) studied Sermorelin effects on GH secretion in children with growth hormone deficiency in clinical trials.

Walker (2006) reviewed Sermorelin's use as a diagnostic agent for pituitary function assessment and its pharmacological profile.

Note: Sermorelin has a clinical development history, unlike many research peptides.

Form & Analytical Testing

Form: Lyophilized powder, 2mg per vial
Appearance: White powder
Molecular Weight: 3357.88 g/mol
For In Vitro Research Use Only

Laboratory Preparation:
Add sterile diluent to vial. Gently swirl until dissolved. Contains methionine.

Solubility Profile: Soluble in water (~2-5 mg/mL), PBS.

Stability: Lyophilized stable 24 months at -20°C. Solution: 14-30 days at 2-8°C.

Historical Note: Sermorelin was previously FDA-approved as Geref for diagnostic evaluation of pituitary function.

Analytical Testing: HPLC, ESI-MS, LAL endotoxin, USP sterility.

This product is for laboratory and in vitro research only. Not for human or animal use.

Article Author

Dr. Sarah Chen, Ph.D.

Biochemistry researcher specializing in neuroendocrine peptide pharmacology.

This content was prepared for informational purposes based on published preclinical research. It does not constitute medical advice or product efficacy claims.

Citations

1
Gelander L, et al. "Sermorelin (GRF 1-29)-stimulated growth hormone secretion in growth hormone deficient children." Eur J Endocrinol. 2012;167(3):329-36. PubMed
2
Walker RF. "Sermorelin: A better approach to management of adult-onset growth hormone insufficiency?" Clin Interv Aging. 2006;1(4):307-8. PubMed

RUO Disclaimer

ALL ARTICLES AND PRODUCT INFORMATION ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. Products are for in-vitro studies only. Not approved by the FDA. Bodily introduction strictly forbidden. These products are not drugs, supplements, food, or cosmetics and may not be acquired for such purposes.

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Properties

Molecular Formula

C149H246N44O42S

Molecular Weight

3357.88 g/mol

Monoisotopic Mass

3356.82

Polar Area

1470 Å²

Complexity

7640

XLogP

-12.1

Heavy Atoms

238

H-Bond Donors

H-Bond Acceptors

Rotatable Bonds

118

Identifiers

PubChem CID

16129620

InChIKey

WGWPRVFKDLAUQJ-MITYVQBRSA-N

IUPAC

(3S)-4-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-4-oxobutanoic acid

Sermorelin (GRF 1-29) 2D Structure

Source: PubChem

99.0%

HPLC Purity

Target: ≥98%

2mg

Peptide Content

3357.9 Da

Mol. Weight (MS)

<0.1 EU/mg

Endotoxins

Pass (USP <71>)

Sterility

Download Full COA (PDF)

Janssen Analytical Laboratories

Salt Lake City, UT 84101

Verified

Test	Target	Result
HPLC Purity	u226598.0%	99.0% ✓
Mass Spectrometry	3357.9 u00b1 2.0 Da	3357.9 Da ✓
Endotoxin (LAL)	<0.1 EU/mg	<0.05 EU/mg ✓
Sterility (USP <71>)	No growth	Pass ✓

Temperature

Lyophilized: -20°C, protected from light
Reconstituted: 2-8°C

Shelf Life

24 months lyophilized at -20°C
30 days reconstituted at 2-8°C

Handling

Allow vial to reach room temperature before opening.
Reconstitute with bacteriostatic water.
Avoid repeated freeze-thaw cycles.
Contains methionine; minimize oxidative exposure.

Frequently Asked Questions

Sermorelin is verified at ≥99.0% purity via reverse-phase HPLC analysis. Each batch also undergoes ESI mass spectrometry for identity confirmation, LAL endotoxin testing (<0.1 EU/mg), and USP <71> sterility testing. A batch-specific Certificate of Analysis (COA) is included with every order.

Add bacteriostatic water (0.9% benzyl alcohol) slowly to the vial wall. Gently swirl to dissolve — do not shake or vortex. Reconstituted peptide should be stored at 2-8°C and used within 30 days. For single-use applications, sterile water may be substituted (no preservative, use immediately).

Lyophilized (powder): Store at -20°C, protected from light and moisture. Shelf life: 24 months. Reconstituted (solution): Store at 2-8°C, use within 30 days. Critical: Allow the vial to reach room temperature before opening to prevent moisture condensation inside the vial. Avoid repeated freeze-thaw cycles (max 3 recommended).

The CAS registry number for Sermorelin is 86168-78-7. Molecular weight: 3357.88 g/mol. Molecular formula: C149H246N44O42S. Full chemical characterization data including PubChem identifiers, SMILES notation, and InChIKey are available on the Chemical Properties tab above.

Yes. Every batch of Sermorelin is independently tested by Janssen Analytical Laboratories (ISO 17025-accredited). Testing includes HPLC purity analysis, mass spectrometry identity confirmation, LAL kinetic turbidimetric endotoxin assay, and USP <71> sterility testing. Full results are provided in the batch-specific COA. Additional documentation is available on the COA/HPLC/MS and 3rd Party Testing tabs above.

Orders placed before 2:00 PM EST ship same day via cold-chain logistics with gel ice packs to maintain product integrity during transit. Most domestic orders arrive within 2-4 business days. Full tracking is provided. All vials are sealed under inert atmosphere and packaged to prevent damage.

Yes. Tiered pricing is applied automatically at checkout: 2+ units at 10% off, 3+ units at 15% off, and 5+ units at 20% off. For institutional or bulk research inquiries (10+ vials), contact us at contact@aureumpeptides.com for custom pricing.

Compatibility depends on your specific experimental design. Sermorelin is provided as a single-compound lyophilized preparation for maximum flexibility. When using multiple compounds, reconstitute each separately and add to experimental systems independently to avoid potential interactions during reconstitution. Check the "Researchers Also Purchased" section below for commonly paired research compounds.

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