Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide belonging to the secretin/glucagon superfamily. First isolated from porcine small intestine by Said and Mutt in 1970, VIP is widely distributed throughout the central and peripheral nervous systems and functions as a neurotransmitter and neuromodulator with diverse biological activities.
VIP has a molecular weight of 3326.8 g/mol. It binds to two G-protein coupled receptors: VPAC1 and VPAC2. Both receptors couple to Gs proteins, leading to cAMP generation. VIP has an alpha-helical secondary structure that is important for receptor binding.
Research Applications
• Neuropeptide biology: Studies on VIP's roles as a neurotransmitter in the CNS and enteric nervous system.
• Immunomodulation: Research on VIP's anti-inflammatory effects through VPAC1/VPAC2 signaling.
• Circadian biology: Studies on VIP's role in SCN clock synchronization.
• Pulmonary biology: Research on VIP's bronchodilatory and vasodilatory effects.
Form & Analytical Testing
Form: Lyophilized powder, 10mg per vial
Appearance: White powder
Solubility: Soluble in water and dilute acetic acid
Full analytical testing per batch.
Article Author
DS
Article Author
Dr. Sarah Chen, Ph.D.
Biochemistry researcher specializing in neuropeptide characterization.
This content was prepared for informational purposes based on published preclinical research. It does not constitute medical advice or product efficacy claims.
Citations
1
Said SI, Mutt V. "Polypeptide with broad biological activity: isolation from small intestine." Science. 1970;169(3951):1217-8. PubMed
2
Delgado M, et al. "Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions." Amino Acids. 2013;45(1):25-39. PubMed
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Properties
Molecular Formula
C147H238N44O43S
Molecular Weight
3326.8 g/mol
Identifiers
PubChem CID
16129672
Vasoactive Intestinal Peptide 2D Structure
Source: PubChem
99.0%
HPLC Purity
Target: ≥98%
10mg
Peptide Content
3326.8 Da
Mol. Weight (MS)
<0.1 EU/mg
Endotoxins
Pass (USP <71>)
Sterility
Janssen Analytical Laboratories
Salt Lake City, UT 84101
Verified
Test
Target
Result
HPLC Purity
u226598.0%
99.0% ✓
Mass Spectrometry
3326.8 u00b1 2.0 Da
3326.8 Da ✓
Endotoxin (LAL)
<0.1 EU/mg
<0.05 EU/mg ✓
Sterility (USP <71>)
No growth
Pass ✓
Temperature
Lyophilized: -20°C, protected from light
Reconstituted: 2-8°C
Shelf Life
24 months lyophilized at -20°C
30 days reconstituted at 2-8°C
Handling
Allow vial to reach room temperature before opening.
Reconstitute with bacteriostatic water or dilute acetic acid.
Avoid repeated freeze-thaw cycles.
Frequently Asked Questions
VIP 10mg is verified at ≥99.0% purity via reverse-phase HPLC analysis. Each batch also undergoes ESI mass spectrometry for identity confirmation, LAL endotoxin testing (<0.1 EU/mg), and USP <71> sterility testing. A batch-specific Certificate of Analysis (COA) is included with every order.
Add bacteriostatic water (0.9% benzyl alcohol) slowly to the vial wall. Gently swirl to dissolve — do not shake or vortex. Solubility: Soluble in water and dilute acetic acid. Reconstituted peptide should be stored at 2-8°C and used within 30 days. For single-use applications, sterile water may be substituted (no preservative, use immediately).
Lyophilized (powder): Store at -20°C, protected from light and moisture. Shelf life: 24 months. Reconstituted (solution): Store at 2-8°C, use within 30 days. Critical: Allow the vial to reach room temperature before opening to prevent moisture condensation inside the vial. Avoid repeated freeze-thaw cycles (max 3 recommended).
The CAS registry number for VIP 10mg is 37221-79-7. Molecular weight: 3326.8 g/mol. Molecular formula: C147H238N44O43S. Full chemical characterization data including PubChem identifiers, SMILES notation, and InChIKey are available on the Chemical Properties tab above.
Yes. Every batch of VIP 10mg is independently tested by Janssen Analytical Laboratories (ISO 17025-accredited). Testing includes HPLC purity analysis, mass spectrometry identity confirmation, LAL kinetic turbidimetric endotoxin assay, and USP <71> sterility testing. Full results are provided in the batch-specific COA. Additional documentation is available on the COA/HPLC/MS and 3rd Party Testing tabs above.
Orders placed before 2:00 PM EST ship same day via cold-chain logistics with gel ice packs to maintain product integrity during transit. Most domestic orders arrive within 2-4 business days. Full tracking is provided. All vials are sealed under inert atmosphere and packaged to prevent damage.
Yes. Tiered pricing is applied automatically at checkout: 2+ units at 10% off, 3+ units at 15% off, and 5+ units at 20% off. For institutional or bulk research inquiries (10+ vials), contact us at contact@aureumpeptides.com for custom pricing.
Compatibility depends on your specific experimental design. VIP 10mg is provided as a single-compound lyophilized preparation for maximum flexibility. When using multiple compounds, reconstitute each separately and add to experimental systems independently to avoid potential interactions during reconstitution. Check the "Researchers Also Purchased" section below for commonly paired research compounds.
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VIP 10mg from Aureum Peptides is synthesized to ≥99% purity and verified by third-party HPLC analysis. A Certificate of Analysis (COA) is included with every order.
Is VIP 10mg intended for human use?+
No. VIP 10mg is sold strictly for in-vitro laboratory research purposes only. Not for human consumption, therapeutic use, or veterinary use. Purchase is limited to qualified researchers and research facilities.
How is VIP 10mg shipped and stored?+
Orders placed before 2:00 PM EST ship the same business day from our USA facility with cold-chain logistics. Upon arrival, store VIP 10mg lyophilized at -20°C for long-term stability, or at 4°C for short-term storage after reconstitution.
Do you provide a Certificate of Analysis?+
Yes. Every vial of VIP 10mg ships with a batch-specific Certificate of Analysis documenting identity (mass spectrometry), purity (HPLC), and appearance. COAs are also accessible via our online COA portal using the batch number on your vial.
Can I order VIP 10mg in bulk for institutional research?+
Yes. Aureum Peptides offers institutional wholesale pricing for universities, biotech R&D, and contract research organizations. Contact us for a quote and Net-30 payment terms after credit approval.
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