Thymalin (glutamyl-tryptophan or EW dipeptide) is a synthetic dipeptide studied by Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology as a thymic peptide bioregulator. It has been studied in immunological research and aging models in Russia for several decades.
Biochemical Characteristics
Specifications
Sequence
L-Glu-L-Trp
Molecular Formula
C16H18N2O6
Molecular Weight
333.34 g/mol
CAS Number
7432-24-8
Thymalin has a molecular weight of 333.34 g/mol. As a dipeptide, it is one of the smallest peptides studied for bioregulatory activity. The glutamic acid-tryptophan combination provides a balance of polar and aromatic properties.
The peptide has been studied as a bioregulator that may interact with gene expression in immune cells through epigenetic mechanisms.
Research Applications
• Immune modulation: Studies examining Thymalin effects on T-cell differentiation and function.
• Thymic biology: Research on thymic involution and peptide-based interventions.
• Aging research: Long-term studies in rodent models examining immune parameters.
• Bioregulation: Research on small peptide effects on gene expression profiles.
Pathway Context
• T-cell maturation and differentiation pathways
• Thymic epithelial cell interaction
• Cytokine production modulation
• Gene expression regulation through peptide bioregulation mechanisms
Preclinical Research
Khavinson et al. (2002) reported Thymalin effects on immune function parameters in aged rodent models.
The peptide bioregulation concept, developed by Khavinson's group, proposes that small peptides can modulate gene expression through interaction with DNA sequences.
Thymalin is registered as a pharmaceutical in Russia.
Form & Analytical Testing
Form: Lyophilized powder, 10mg per vial
Appearance: White to off-white powder
Solubility: Soluble in water
Full analytical testing per batch.
Article Author
DS
Article Author
Dr. Sarah Chen, Ph.D.
Biochemistry researcher specializing in immunopeptide research.
This content was prepared for informational purposes based on published preclinical research. It does not constitute medical advice or product efficacy claims.
Citations
1
Khavinson V, et al. "Peptide regulation of gene expression and protein synthesis in bronchial epithelium." Lung. 2014;192(5):781-91. PubMed
2
Khavinson VKh. "Peptides and Ageing." Neuroendocrinol Lett. 2002;23(Suppl 3):11-144. PubMed
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ALL ARTICLES AND PRODUCT INFORMATION ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. Products are for in-vitro studies only. Not approved by the FDA. Bodily introduction strictly forbidden. These products are not drugs, supplements, food, or cosmetics and may not be acquired for such purposes.
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Lyophilized: -20°C, protected from light
Reconstituted: 2-8°C
Shelf Life
24 months lyophilized at -20°C
30 days reconstituted at 2-8°C
Handling
Allow vial to reach room temperature before opening.
Reconstitute with bacteriostatic water.
Avoid repeated freeze-thaw cycles.
Frequently Asked Questions
Thymalin is verified at ≥99.2% purity via reverse-phase HPLC analysis. Each batch also undergoes ESI mass spectrometry for identity confirmation, LAL endotoxin testing (<0.1 EU/mg), and USP <71> sterility testing. A batch-specific Certificate of Analysis (COA) is included with every order.
Add bacteriostatic water (0.9% benzyl alcohol) slowly to the vial wall. Gently swirl to dissolve — do not shake or vortex. Solubility: Soluble in water. Reconstituted peptide should be stored at 2-8°C and used within 30 days. For single-use applications, sterile water may be substituted (no preservative, use immediately).
Lyophilized (powder): Store at -20°C, protected from light and moisture. Shelf life: 24 months. Reconstituted (solution): Store at 2-8°C, use within 30 days. Critical: Allow the vial to reach room temperature before opening to prevent moisture condensation inside the vial. Avoid repeated freeze-thaw cycles (max 3 recommended).
The CAS registry number for Thymalin is 7432-24-8. Molecular weight: 333.34 g/mol. Molecular formula: C16H18N2O6. Full chemical characterization data including PubChem identifiers, SMILES notation, and InChIKey are available on the Chemical Properties tab above.
Yes. Every batch of Thymalin is independently tested by Janssen Analytical Laboratories (ISO 17025-accredited). Testing includes HPLC purity analysis, mass spectrometry identity confirmation, LAL kinetic turbidimetric endotoxin assay, and USP <71> sterility testing. Full results are provided in the batch-specific COA. Additional documentation is available on the COA/HPLC/MS and 3rd Party Testing tabs above.
Orders placed before 2:00 PM EST ship same day via cold-chain logistics with gel ice packs to maintain product integrity during transit. Most domestic orders arrive within 2-4 business days. Full tracking is provided. All vials are sealed under inert atmosphere and packaged to prevent damage.
Yes. Tiered pricing is applied automatically at checkout: 2+ units at 10% off, 3+ units at 15% off, and 5+ units at 20% off. For institutional or bulk research inquiries (10+ vials), contact us at contact@aureumpeptides.com for custom pricing.
Compatibility depends on your specific experimental design. Thymalin is provided as a single-compound lyophilized preparation for maximum flexibility. When using multiple compounds, reconstitute each separately and add to experimental systems independently to avoid potential interactions during reconstitution. Check the "Researchers Also Purchased" section below for commonly paired research compounds.
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