SNAP-8 (acetyl octapeptide-3) is a synthetic octapeptide designed as a mimic of the N-terminal domain of SNAP-25, a component of the SNARE complex involved in neurotransmitter vesicle fusion. Developed by Lipotec (now Lubrizol), SNAP-8 has been studied for its effects on SNARE complex assembly in in vitro models of neuromuscular signaling.
Biochemical Characteristics
Specifications
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Molecular Formula
C41H70N16O16S
Molecular Weight
1075.16 g/mol
CAS Number
868844-74-0
SNAP-8 has a molecular weight of 1075.16 g/mol and is an N-acetylated octapeptide. The sequence mimics a portion of SNAP-25, one of three proteins that form the SNARE complex (SNAP-25, syntaxin-1, and VAMP) required for synaptic vesicle exocytosis.
The acetyl group on the N-terminus enhances membrane permeability and metabolic stability.
Research Applications
• SNARE complex biology: Studies examining SNAP-8's competitive inhibition of SNARE complex assembly in cell-free and cell-based assays.
• Neuromuscular junction research: In vitro studies on neurotransmitter release modulation.
• Cosmeceutical peptide research: Studies comparing SNAP-8 with other peptide approaches to SNARE modulation.
• Structure-activity: Comparative studies with hexapeptide (Argireline) and octapeptide (SNAP-8) SNARE mimetics.
Lipotec technical documentation reports in vitro SNARE complex inhibition assays demonstrating dose-dependent effects on complex assembly.
SNAP-8 is widely used in cosmeceutical research and has an established safety profile for topical applications.
Form & Analytical Testing
Form: Lyophilized powder, 10mg per vial
Appearance: White powder
Solubility: Highly water-soluble
Full analytical testing per batch.
Article Author
DS
Article Author
Dr. Sarah Chen, Ph.D.
Biochemistry researcher specializing in neuropeptide and cosmeceutical peptide research.
This content was prepared for informational purposes based on published preclinical research. It does not constitute medical advice or product efficacy claims.
Citations
1
Blanes-Mira C, et al. "A synthetic hexapeptide (Argireline) with antiwrinkle activity." Int J Cosmet Sci. 2002;24(5):303-10. PubMed
2
Ferrer-Montiel A, et al. "Small molecules targeting the SNARE complex." Curr Pharm Des. 2009;15(31):3638-47. PubMed
RUO Disclaimer
ALL ARTICLES AND PRODUCT INFORMATION ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. Products are for in-vitro studies only. Not approved by the FDA. Bodily introduction strictly forbidden. These products are not drugs, supplements, food, or cosmetics and may not be acquired for such purposes.
Advancing Research, One Peptide at a Time
Premium quality. Rigorous testing. Trusted by researchers worldwide.
Properties
Molecular Formula
C41H70N16O16S
Molecular Weight
1075.16 g/mol
Monoisotopic Mass
1074.49
Heavy Atoms
74
Identifiers
PubChem CID
20830754
Snap-8 (Acetyl Octapeptide-3) 2D Structure
Source: PubChem
99.0%
HPLC Purity
Target: ≥98%
10mg
Peptide Content
1075.2 Da
Mol. Weight (MS)
<0.1 EU/mg
Endotoxins
Pass (USP <71>)
Sterility
Janssen Analytical Laboratories
Salt Lake City, UT 84101
Verified
Test
Target
Result
HPLC Purity
u226598.0%
99.0% ✓
Mass Spectrometry
1075.2 u00b1 1.0 Da
1075.2 Da ✓
Endotoxin (LAL)
<0.1 EU/mg
<0.05 EU/mg ✓
Sterility (USP <71>)
No growth
Pass ✓
Temperature
Lyophilized: -20°C, protected from light
Reconstituted: 2-8°C
Shelf Life
24 months lyophilized at -20°C
30 days reconstituted at 2-8°C
Handling
Allow vial to reach room temperature before opening.
Reconstitute with bacteriostatic water.
Avoid repeated freeze-thaw cycles.
Frequently Asked Questions
Snap-8 is verified at ≥99.0% purity via reverse-phase HPLC analysis. Each batch also undergoes ESI mass spectrometry for identity confirmation, LAL endotoxin testing (<0.1 EU/mg), and USP <71> sterility testing. A batch-specific Certificate of Analysis (COA) is included with every order.
Add bacteriostatic water (0.9% benzyl alcohol) slowly to the vial wall. Gently swirl to dissolve — do not shake or vortex. Solubility: Highly water-soluble. Reconstituted peptide should be stored at 2-8°C and used within 30 days. For single-use applications, sterile water may be substituted (no preservative, use immediately).
Lyophilized (powder): Store at -20°C, protected from light and moisture. Shelf life: 24 months. Reconstituted (solution): Store at 2-8°C, use within 30 days. Critical: Allow the vial to reach room temperature before opening to prevent moisture condensation inside the vial. Avoid repeated freeze-thaw cycles (max 3 recommended).
The CAS registry number for Snap-8 is 868844-74-0. Molecular weight: 1075.16 g/mol. Molecular formula: C41H70N16O16S. Full chemical characterization data including PubChem identifiers, SMILES notation, and InChIKey are available on the Chemical Properties tab above.
Yes. Every batch of Snap-8 is independently tested by Janssen Analytical Laboratories (ISO 17025-accredited). Testing includes HPLC purity analysis, mass spectrometry identity confirmation, LAL kinetic turbidimetric endotoxin assay, and USP <71> sterility testing. Full results are provided in the batch-specific COA. Additional documentation is available on the COA/HPLC/MS and 3rd Party Testing tabs above.
Orders placed before 2:00 PM EST ship same day via cold-chain logistics with gel ice packs to maintain product integrity during transit. Most domestic orders arrive within 2-4 business days. Full tracking is provided. All vials are sealed under inert atmosphere and packaged to prevent damage.
Yes. Tiered pricing is applied automatically at checkout: 2+ units at 10% off, 3+ units at 15% off, and 5+ units at 20% off. For institutional or bulk research inquiries (10+ vials), contact us at contact@aureumpeptides.com for custom pricing.
Compatibility depends on your specific experimental design. Snap-8 is provided as a single-compound lyophilized preparation for maximum flexibility. When using multiple compounds, reconstitute each separately and add to experimental systems independently to avoid potential interactions during reconstitution. Check the "Researchers Also Purchased" section below for commonly paired research compounds.
Stay at the Forefront
Join our research community. Get early access to new peptides, exclusive member pricing, and curated literature reviews delivered to your inbox.
Welcome to the Circle ✦
Check your inbox for your 10% welcome discount
No spam, everUnsubscribe anytime12,000+ researchers
CA Prop 65: WARNING: This product can expose you to chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm. P65Warnings.ca.gov
Side-by-side analysis of chemical profiles, research applications, and specifications
All products are sold strictly for in vitro research and laboratory use. Not for human consumption, therapeutic use, or veterinary use. No statements on this website have been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you confirm you are a qualified researcher and agree to our Terms of Service. CA Prop 65 Warning: Products may contain chemicals known to the State of California to cause cancer or reproductive harm.
Research Grade Peptides
USA Based
Same-Day Shipping
99%+ Purity Verified
Stay Informed
Get research updates, new product alerts, and exclusive offers delivered to your inbox.
No spam. Research content only. Unsubscribe anytime.
All products are sold strictly for laboratory research and in-vitro testing. Not for human consumption.
Product Comparison
Join the Aureum Research Community
Get early access to new compounds, exclusive protocols, and research updates.
Snap-8 from Aureum Peptides is synthesized to ≥99% purity and verified by third-party HPLC analysis. A Certificate of Analysis (COA) is included with every order.
Is Snap-8 intended for human use?+
No. Snap-8 is sold strictly for in-vitro laboratory research purposes only. Not for human consumption, therapeutic use, or veterinary use. Purchase is limited to qualified researchers and research facilities.
How is Snap-8 shipped and stored?+
Orders placed before 2:00 PM EST ship the same business day from our USA facility with cold-chain logistics. Upon arrival, store Snap-8 lyophilized at -20°C for long-term stability, or at 4°C for short-term storage after reconstitution.
Do you provide a Certificate of Analysis?+
Yes. Every vial of Snap-8 ships with a batch-specific Certificate of Analysis documenting identity (mass spectrometry), purity (HPLC), and appearance. COAs are also accessible via our online COA portal using the batch number on your vial.
Can I order Snap-8 in bulk for institutional research?+
Yes. Aureum Peptides offers institutional wholesale pricing for universities, biotech R&D, and contract research organizations. Contact us for a quote and Net-30 payment terms after credit approval.
No reviews yet. Be the first to share your experience with this product.
Write a Review
Review Guidelines: Reviews must relate to product quality, packaging, shipping experience, and research-grade specifications only. Reviews describing personal use, health effects, or therapeutic outcomes will not be published.
All reviews are moderated before publication to ensure compliance with research-use-only guidelines.
