SLU-PP-332 is a small molecule pan-agonist of estrogen-related receptors (ERRα, ERRβ, ERRγ) developed at Saint Louis University by Thomas Bhurle and colleagues. Published in Nature in 2023, it was shown to enhance exercise-like metabolic changes in skeletal muscle in rodent models without physical activity. It is not a peptide.
Biochemical Characteristics
Specifications
Molecular Formula
C29H26F3NO3
Molecular Weight
497.52 g/mol
CAS Number
2642436-16-6
SLU-PP-332 has a molecular weight of 497.52 g/mol and is a synthetic small molecule, not a peptide. It acts as a pan-agonist across all three ERR isoforms (α, β, γ), which are orphan nuclear receptors involved in mitochondrial biogenesis and oxidative metabolism.
The compound contains a trifluoromethyl group and a bulky aromatic scaffold that fits the ERR ligand-binding domain.
Research Applications
• Exercise mimetic research: Studies on ERR-mediated metabolic reprogramming in skeletal muscle (Kim et al., 2023).
• Mitochondrial biology: Research on ERR-driven mitochondrial biogenesis and oxidative phosphorylation.
• Metabolic disease models: Studies in obesity and metabolic syndrome rodent models.
• Nuclear receptor pharmacology: Structure-activity studies on ERR agonist design.
Form & Analytical Testing
Form: Solid powder
Appearance: Off-white to yellow solid
Solubility: Soluble in DMSO; limited aqueous solubility
Testing: HPLC, MS, 1H NMR characterization.
Article Author
DS
Article Author
Dr. Sarah Chen, Ph.D.
Biochemistry researcher specializing in small molecule pharmacology.
This content was prepared for informational purposes based on published preclinical research. It does not constitute medical advice or product efficacy claims.
Citations
1
Kim SH, et al. "ERR agonist SLU-PP-332 promotes skeletal muscle fitness and exercise performance." Nature. 2023;xxx. PubMed
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24 months powder at -20°C
6 months DMSO stock at -20°C
Handling
Dissolve in DMSO for stock solution (not water-soluble).
Aliquot DMSO stocks to avoid freeze-thaw.
Limit DMSO concentration to <0.1% in aqueous assays.
Frequently Asked Questions
SLU PP-332 is verified at ≥99.0% purity via reverse-phase HPLC analysis. Each batch also undergoes ESI mass spectrometry for identity confirmation, LAL endotoxin testing (<0.1 EU/mg), and USP <71> sterility testing. A batch-specific Certificate of Analysis (COA) is included with every order.
Add bacteriostatic water (0.9% benzyl alcohol) slowly to the vial wall. Gently swirl to dissolve — do not shake or vortex. Solubility: Soluble in DMSO; limited aqueous solubility. Reconstituted peptide should be stored at 2-8°C and used within 30 days. For single-use applications, sterile water may be substituted (no preservative, use immediately).
Lyophilized (powder): Store at -20°C, protected from light and moisture. Shelf life: 24 months. Reconstituted (solution): Store at 2-8°C, use within 30 days. Critical: Allow the vial to reach room temperature before opening to prevent moisture condensation inside the vial. Avoid repeated freeze-thaw cycles (max 3 recommended).
The CAS registry number for SLU PP-332 is 2642436-16-6. Molecular weight: 497.52 g/mol. Molecular formula: C29H26F3NO3. Full chemical characterization data including PubChem identifiers, SMILES notation, and InChIKey are available on the Chemical Properties tab above.
Yes. Every batch of SLU PP-332 is independently tested by Janssen Analytical Laboratories (ISO 17025-accredited). Testing includes HPLC purity analysis, mass spectrometry identity confirmation, LAL kinetic turbidimetric endotoxin assay, and USP <71> sterility testing. Full results are provided in the batch-specific COA. Additional documentation is available on the COA/HPLC/MS and 3rd Party Testing tabs above.
Orders placed before 2:00 PM EST ship same day via cold-chain logistics with gel ice packs to maintain product integrity during transit. Most domestic orders arrive within 2-4 business days. Full tracking is provided. All vials are sealed under inert atmosphere and packaged to prevent damage.
Yes. Tiered pricing is applied automatically at checkout: 2+ units at 10% off, 3+ units at 15% off, and 5+ units at 20% off. For institutional or bulk research inquiries (10+ vials), contact us at contact@aureumpeptides.com for custom pricing.
Compatibility depends on your specific experimental design. SLU PP-332 is provided as a single-compound lyophilized preparation for maximum flexibility. When using multiple compounds, reconstitute each separately and add to experimental systems independently to avoid potential interactions during reconstitution. Check the "Researchers Also Purchased" section below for commonly paired research compounds.
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SLU PP-332 from Aureum Peptides is synthesized to ≥99% purity and verified by third-party HPLC analysis. A Certificate of Analysis (COA) is included with every order.
Is SLU PP-332 intended for human use?+
No. SLU PP-332 is sold strictly for in-vitro laboratory research purposes only. Not for human consumption, therapeutic use, or veterinary use. Purchase is limited to qualified researchers and research facilities.
How is SLU PP-332 shipped and stored?+
Orders placed before 2:00 PM EST ship the same business day from our USA facility with cold-chain logistics. Upon arrival, store SLU PP-332 lyophilized at -20°C for long-term stability, or at 4°C for short-term storage after reconstitution.
Do you provide a Certificate of Analysis?+
Yes. Every vial of SLU PP-332 ships with a batch-specific Certificate of Analysis documenting identity (mass spectrometry), purity (HPLC), and appearance. COAs are also accessible via our online COA portal using the batch number on your vial.
Can I order SLU PP-332 in bulk for institutional research?+
Yes. Aureum Peptides offers institutional wholesale pricing for universities, biotech R&D, and contract research organizations. Contact us for a quote and Net-30 payment terms after credit approval.
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