N-Acetyl Selank is an N-terminally acetylated derivative of the heptapeptide Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro). The acetyl modification at the N-terminus enhances metabolic stability and extends the peptide's biological half-life compared to unmodified Selank. Like its parent compound, it is based on the tuftsin immunomodulatory peptide scaffold.
Biochemical Characteristics
Specifications
Sequence
Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro
Molecular Formula
C38H57N11O10
Molecular Weight
847.93 g/mol
CAS Number
129954-34-3
N-Acetyl Selank has a molecular weight of approximately 847.93 g/mol. The N-acetylation protects the peptide from aminopeptidase degradation, enhancing its stability and bioavailability compared to native Selank. The core tuftsin sequence and Pro-Gly-Pro extension are preserved, maintaining the functional properties of the parent compound.
Research Applications
• Enhanced stability studies: Comparative pharmacokinetic studies between acetylated and non-acetylated Selank.
• Anxiolytic research: Studies examining N-Acetyl Selank in rodent behavioral models.
• Immunomodulation: Research on cytokine modulation with improved peptide stability.
• BDNF expression: Studies on neurotrophic factor expression in neuronal models.
Pathway Context
• Same core pathways as Selank with enhanced duration
• GABA-A receptor system interaction
• Enkephalinase inhibition
• BDNF/NGF expression modulation
• IL-6 and cytokine profile regulation
Preclinical Research
Research on N-Acetyl Selank largely parallels Selank studies with the additional benefit of enhanced metabolic stability.
The N-acetyl modification is a well-established strategy for improving peptide pharmacokinetics without altering receptor interactions.
Form & Analytical Testing
Form: Lyophilized powder, 5mg per vial
Appearance: White powder
Solubility: Soluble in water and bacteriostatic water
Full analytical testing per batch.
Article Author
DS
Article Author
Dr. Sarah Chen, Ph.D.
Biochemistry researcher specializing in modified peptide design.
This content was prepared for informational purposes based on published preclinical research. It does not constitute medical advice or product efficacy claims.
Citations
1
Seredenin SB, et al. "Anxiolytic-like effect of selank in comparison with nozepam." Bull Exp Biol Med. 2009;148(1):80-3. PubMed
2
Uchakina ON, et al. "Immunomodulatory effects of selank." Bull Exp Biol Med. 2008;146(3):353-5. PubMed
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ALL ARTICLES AND PRODUCT INFORMATION ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. Products are for in-vitro studies only. Not approved by the FDA. Bodily introduction strictly forbidden. These products are not drugs, supplements, food, or cosmetics and may not be acquired for such purposes.
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Properties
Molecular Formula
C38H57N11O10
Molecular Weight
847.93 g/mol
Selank Core Structure (N-Acetylated Form)
Source: PubChem
99.0%
HPLC Purity
Target: ≥98%
5mg
Peptide Content
847.9 Da
Mol. Weight (MS)
<0.1 EU/mg
Endotoxins
Pass (USP <71>)
Sterility
Janssen Analytical Laboratories
Salt Lake City, UT 84101
Verified
Test
Target
Result
HPLC Purity
u226598.0%
99.0% ✓
Mass Spectrometry
847.9 u00b1 0.5 Da
847.9 Da ✓
Endotoxin (LAL)
<0.1 EU/mg
<0.05 EU/mg ✓
Sterility (USP <71>)
No growth
Pass ✓
Temperature
Lyophilized: -20°C, protected from light
Reconstituted: 2-8°C
Shelf Life
24 months lyophilized at -20°C
30 days reconstituted at 2-8°C
Handling
Allow vial to reach room temperature before opening.
Reconstitute with bacteriostatic water.
Avoid repeated freeze-thaw cycles.
Frequently Asked Questions
N-Acetyl Selank is verified at ≥99.0% purity via reverse-phase HPLC analysis. Each batch also undergoes ESI mass spectrometry for identity confirmation, LAL endotoxin testing (<0.1 EU/mg), and USP <71> sterility testing. A batch-specific Certificate of Analysis (COA) is included with every order.
Add bacteriostatic water (0.9% benzyl alcohol) slowly to the vial wall. Gently swirl to dissolve — do not shake or vortex. Solubility: Soluble in water and bacteriostatic water. Reconstituted peptide should be stored at 2-8°C and used within 30 days. For single-use applications, sterile water may be substituted (no preservative, use immediately).
Lyophilized (powder): Store at -20°C, protected from light and moisture. Shelf life: 24 months. Reconstituted (solution): Store at 2-8°C, use within 30 days. Critical: Allow the vial to reach room temperature before opening to prevent moisture condensation inside the vial. Avoid repeated freeze-thaw cycles (max 3 recommended).
The CAS registry number for N-Acetyl Selank is 129954-34-3. Molecular weight: 847.93 g/mol. Molecular formula: C38H57N11O10. Full chemical characterization data including PubChem identifiers, SMILES notation, and InChIKey are available on the Chemical Properties tab above.
Yes. Every batch of N-Acetyl Selank is independently tested by Janssen Analytical Laboratories (ISO 17025-accredited). Testing includes HPLC purity analysis, mass spectrometry identity confirmation, LAL kinetic turbidimetric endotoxin assay, and USP <71> sterility testing. Full results are provided in the batch-specific COA. Additional documentation is available on the COA/HPLC/MS and 3rd Party Testing tabs above.
Orders placed before 2:00 PM EST ship same day via cold-chain logistics with gel ice packs to maintain product integrity during transit. Most domestic orders arrive within 2-4 business days. Full tracking is provided. All vials are sealed under inert atmosphere and packaged to prevent damage.
Yes. Tiered pricing is applied automatically at checkout: 2+ units at 10% off, 3+ units at 15% off, and 5+ units at 20% off. For institutional or bulk research inquiries (10+ vials), contact us at contact@aureumpeptides.com for custom pricing.
Compatibility depends on your specific experimental design. N-Acetyl Selank is provided as a single-compound lyophilized preparation for maximum flexibility. When using multiple compounds, reconstitute each separately and add to experimental systems independently to avoid potential interactions during reconstitution. Check the "Researchers Also Purchased" section below for commonly paired research compounds.
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