83-amino acid IGF-1 analog with enhanced IGFBP resistance. ≥98% purity. 1mg lyophilized. Widely used cell culture supplement for proliferation and differentiation studies.
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IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1) is an 83-amino acid analog of human IGF-1 with a 13-amino acid N-terminal extension and an Arg substitution at position 3. These modifications reduce binding to IGF-binding proteins (IGFBPs), resulting in enhanced bioavailability compared to native IGF-1 in in vitro assays.
Biochemical Characteristics
Specifications
Molecular Formula
C400H625N111O115S9
Molecular Weight
~9111 g/mol
CAS Number
946870-92-4
IGF-1 LR3 has an approximate molecular weight of 9,111 g/mol. The 13-amino acid N-terminal extension and Arg3 substitution dramatically reduce IGFBP binding affinity, resulting in higher free IGF-1 receptor activation in cell culture systems compared to native IGF-1.
The protein contains three disulfide bonds essential for maintaining biological activity.
Research Applications
• Cell culture: Widely used as a cell culture supplement to promote cell proliferation and inhibit apoptosis.
• IGF receptor biology: Studies on IGF-1R signaling pathways with reduced IGFBP interference.
• Growth factor research: Investigations into IGF-1 signaling in muscle, bone, and metabolic models.
• Stem cell biology: Used in various stem cell maintenance and differentiation protocols.
Form & Analytical Testing
Form: Lyophilized powder, 1mg per vial
Appearance: White powder
Solubility: Soluble in 0.1M acetic acid or acidic buffer
Full analytical testing per batch.
Article Author
DS
Article Author
Dr. Sarah Chen, Ph.D.
Biochemistry researcher specializing in growth factor biology.
This content was prepared for informational purposes based on published preclinical research. It does not constitute medical advice or product efficacy claims.
Citations
1
Francis GL, et al. "Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency." J Mol Endocrinol. 1992;8(3):213-23. PubMed
RUO Disclaimer
ALL ARTICLES AND PRODUCT INFORMATION ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. Products are for in-vitro studies only. Not approved by the FDA. Bodily introduction strictly forbidden. These products are not drugs, supplements, food, or cosmetics and may not be acquired for such purposes.
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Properties
Molecular Formula
C400H625N111O115S9
Molecular Weight
~9111 g/mol
IGF-1 Reference Structure
Source: PubChem
98.5%
HPLC Purity
Target: ≥98%
1mg
Peptide Content
~9111 Da
Mol. Weight (MS)
<0.1 EU/mg
Endotoxins
Pass (USP <71>)
Sterility
Janssen Analytical Laboratories
Salt Lake City, UT 84101
Verified
Test
Target
Result
HPLC Purity
u226595.0%
98.5% ✓
Mass Spectrometry
9111 u00b1 5 Da
9111 Da ✓
Endotoxin (LAL)
<0.1 EU/mg
<0.05 EU/mg ✓
Sterility (USP <71>)
No growth
Pass ✓
Temperature
Lyophilized: -20°C to -80°C, protected from light
Reconstituted: 2-8°C, use within 7 days
Shelf Life
18 months lyophilized at -20°C
7 days reconstituted at 2-8°C
Handling
Reconstitute with 0.1M acetic acid (not bacteriostatic water).
Aliquot to avoid freeze-thaw.
Handle with care — large protein.
Frequently Asked Questions
IGF-1 LR3 is verified at ≥98.5% purity via reverse-phase HPLC analysis. Each batch also undergoes ESI mass spectrometry for identity confirmation, LAL endotoxin testing (<0.1 EU/mg), and USP <71> sterility testing. A batch-specific Certificate of Analysis (COA) is included with every order.
Add bacteriostatic water (0.9% benzyl alcohol) slowly to the vial wall. Gently swirl to dissolve — do not shake or vortex. Solubility: Soluble in 0.1M acetic acid or acidic buffer. Reconstituted peptide should be stored at 2-8°C and used within 30 days. For single-use applications, sterile water may be substituted (no preservative, use immediately).
Lyophilized (powder): Store at -20°C, protected from light and moisture. Shelf life: 24 months. Reconstituted (solution): Store at 2-8°C, use within 30 days. Critical: Allow the vial to reach room temperature before opening to prevent moisture condensation inside the vial. Avoid repeated freeze-thaw cycles (max 3 recommended).
The CAS registry number for IGF-1 LR3 is 946870-92-4. Molecular weight: ~9111 g/mol. Molecular formula: C400H625N111O115S9. Full chemical characterization data including PubChem identifiers, SMILES notation, and InChIKey are available on the Chemical Properties tab above.
Yes. Every batch of IGF-1 LR3 is independently tested by Janssen Analytical Laboratories (ISO 17025-accredited). Testing includes HPLC purity analysis, mass spectrometry identity confirmation, LAL kinetic turbidimetric endotoxin assay, and USP <71> sterility testing. Full results are provided in the batch-specific COA. Additional documentation is available on the COA/HPLC/MS and 3rd Party Testing tabs above.
Orders placed before 2:00 PM EST ship same day via cold-chain logistics with gel ice packs to maintain product integrity during transit. Most domestic orders arrive within 2-4 business days. Full tracking is provided. All vials are sealed under inert atmosphere and packaged to prevent damage.
Yes. Tiered pricing is applied automatically at checkout: 2+ units at 10% off, 3+ units at 15% off, and 5+ units at 20% off. For institutional or bulk research inquiries (10+ vials), contact us at contact@aureumpeptides.com for custom pricing.
Compatibility depends on your specific experimental design. IGF-1 LR3 is provided as a single-compound lyophilized preparation for maximum flexibility. When using multiple compounds, reconstitute each separately and add to experimental systems independently to avoid potential interactions during reconstitution. Check the "Researchers Also Purchased" section below for commonly paired research compounds.
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IGF-1 LR3$35.00–$100.00Price range: $35.00 through $100.00
CA Prop 65: WARNING: This product can expose you to chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm. P65Warnings.ca.gov
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