IGF-1 LR3
83-amino acid IGF-1 analog with enhanced IGFBP resistance. ≥98% purity. 1mg lyophilized. Widely used cell culture supplement for proliferation and differentiation studies.
Overview
IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a modified IGF-1 with an arginine substitution at position 3 and a 13-amino acid N-terminal extension. Modified form of IGF-1 with reduced IGF binding protein affinity and extended half-life.
Published Research
Published literature has examined IGF-1 LR3 across multiple research contexts:
- Reduced IGFBP binding resulting in increased bioavailability in research models
- IGF-1 receptor activation and downstream PI3K/Akt signaling
- Cell proliferation and differentiation pathway studies
- Myogenic and metabolic research biomarker analysis
| Molecular Formula | C400H625N111O115S9 |
|---|---|
| Molecular Weight | ~9111 g/mol |
| CAS Number | 946870-92-4 |
| Amino Acid Count | 83 |
| Purity | ≥98.5% (HPLC verified) |
| Physical Form | White lyophilized powder |
| Storage | -20°C recommended, protect from light |
| SKU | IGF1LR3 |
• Cell culture: Widely used as a cell culture supplement to promote cell proliferation and inhibit apoptosis.
• IGF receptor biology: Studies on IGF-1R signaling pathways with reduced IGFBP interference.
• Growth factor research: Investigations into IGF-1 signaling in muscle, bone, and metabolic models.
• Stem cell biology: Used in various stem cell maintenance and differentiation protocols.
Standard reconstitution: 1 mL bacteriostatic water per vial unless otherwise specified on the Certificate of Analysis. Store reconstituted solution at 2-8°C and use within 30 days. Lyophilized powder stable at -20°C for 24 months when sealed under inert atmosphere.
Every lot ships with a third-party HPLC certificate. View the most recent lot certificate via the COA Portal. Mass spectrometry confirmation available on request.
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