FOXO4-DRI
D-retro-inverso 46-amino acid senolytic peptide. ≥98% purity. 2mg lyophilized. Disrupts FOXO4-p53 interaction in senescent cells. Novel aging biology tool.
Overview
FOXO4-DRI (FOXO4-D-Retro-Inverso) is a rationally designed D-retro-inverso peptide that disrupts FOXO4-p53 interaction. Designed to interfere with the FOXO4-p53 protein-protein interaction in senescent cells.
Published Research
Published literature has examined FOXO4-DRI across multiple research contexts:
- FOXO4-p53 interaction disruption in cellular senescence models
- Senolytic pathway research - selective clearance of senescent cells
- D-retro-inverso modification provides protease resistance
- Longevity and cellular aging research in published preclinical studies
| Molecular Formula | C263H406N76O68S2 |
|---|---|
| Molecular Weight | ~5647 g/mol |
| CAS Number | 2229397-18-2 |
| Amino Acid Count | 46 |
| Purity | ≥98.5% (HPLC verified) |
| Physical Form | White lyophilized powder |
| Storage | -20°C recommended, protect from light |
| SKU | FOXO4-10MG |
• Cellular senescence: Studies examining FOXO4-DRI-induced selective apoptosis in senescent cells (Baar et al., 2017).
• Aging biology: Research on senolytic interventions and their effects on age-related phenotypes in mouse models.
• Protein-protein interaction: Studies on DRI peptide design for disrupting transcription factor complexes.
• Senescence-associated secretory phenotype (SASP): Research on reducing SASP factors through senescent cell clearance.
Standard reconstitution: 1 mL bacteriostatic water per vial unless otherwise specified on the Certificate of Analysis. Store reconstituted solution at 2-8°C and use within 30 days. Lyophilized powder stable at -20°C for 24 months when sealed under inert atmosphere.
Every lot ships with a third-party HPLC certificate. View the most recent lot certificate via the COA Portal. Mass spectrometry confirmation available on request.
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