Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide first isolated from the cerebral venous blood of rabbits during electrically induced slow-wave sleep by Schoenenberger and Monnier in 1977. It has been studied for its effects on sleep architecture, stress response, and neuroendocrine modulation in preclinical research.
Biochemical Characteristics
Specifications
Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Molecular Formula
C35H48N10O15
Molecular Weight
848.81 g/mol
CAS Number
62568-57-4
DSIP has a molecular weight of 848.81 g/mol. It contains an N-terminal tryptophan residue that is important for biological activity. The peptide is found in both free and bound forms in plasma and cerebrospinal fluid, with the bound form serving as a potential reservoir.
DSIP demonstrates amphiphilic properties allowing it to cross biological membranes in in vitro models.
Research Applications
• Sleep architecture: Studies examining DSIP effects on delta wave (slow-wave) sleep patterns in animal EEG models (Schneider-Helmert, 1985).
• Stress response: Research on DSIP's interaction with cortisol and ACTH release patterns.
• Pain biology: Studies examining DSIP in pain threshold models.
• Neuroendocrine regulation: Research on DSIP's effects on LH, GH, and TSH secretion patterns.
Pathway Context
• Delta-opioid receptor interaction
• GABA-ergic system modulation
• HPA axis regulation (CRH/ACTH/cortisol)
• Serotonin and dopamine system interaction
• Endogenous opioid peptide system modulation
Preclinical Research
Schneider-Helmert (1985) reported DSIP effects on sleep architecture in human subjects, particularly increased slow-wave sleep duration.
Graf and Kastin (1986) reviewed DSIP's physiological roles including effects on cortisol rhythm and pain threshold modulation in animal models.
DSIP has not undergone regulatory approval in any jurisdiction.
Form & Analytical Testing
Form: Lyophilized powder, 5mg per vial
Appearance: White powder
Solubility: Soluble in water and bacteriostatic water
Full analytical testing per batch.
Article Author
DS
Article Author
Dr. Sarah Chen, Ph.D.
Biochemistry researcher specializing in neuropeptide characterization.
This content was prepared for informational purposes based on published preclinical research. It does not constitute medical advice or product efficacy claims.
Citations
1
Schneider-Helmert D. "Effects of DSIP on narcolepsy and insomnia." Eur Neurol. 1985;24(S2):128-34. PubMed
2
Graf MV, Kastin AJ. "Delta-sleep-inducing peptide (DSIP): a review." Neurosci Biobehav Rev. 1984;8(1):83-93. PubMed
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ALL ARTICLES AND PRODUCT INFORMATION ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. Products are for in-vitro studies only. Not approved by the FDA. Bodily introduction strictly forbidden. These products are not drugs, supplements, food, or cosmetics and may not be acquired for such purposes.
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Lyophilized: -20°C, protected from light
Reconstituted: 2-8°C
Shelf Life
24 months lyophilized at -20°C
30 days reconstituted at 2-8°C
Handling
Allow vial to reach room temperature before opening.
Reconstitute with bacteriostatic water.
Avoid repeated freeze-thaw cycles.
Frequently Asked Questions
DSIP is verified at ≥99.1% purity via reverse-phase HPLC analysis. Each batch also undergoes ESI mass spectrometry for identity confirmation, LAL endotoxin testing (<0.1 EU/mg), and USP <71> sterility testing. A batch-specific Certificate of Analysis (COA) is included with every order.
Add bacteriostatic water (0.9% benzyl alcohol) slowly to the vial wall. Gently swirl to dissolve — do not shake or vortex. Solubility: Soluble in water and bacteriostatic water. Reconstituted peptide should be stored at 2-8°C and used within 30 days. For single-use applications, sterile water may be substituted (no preservative, use immediately).
Lyophilized (powder): Store at -20°C, protected from light and moisture. Shelf life: 24 months. Reconstituted (solution): Store at 2-8°C, use within 30 days. Critical: Allow the vial to reach room temperature before opening to prevent moisture condensation inside the vial. Avoid repeated freeze-thaw cycles (max 3 recommended).
The CAS registry number for DSIP is 62568-57-4. Molecular weight: 848.81 g/mol. Molecular formula: C35H48N10O15. Full chemical characterization data including PubChem identifiers, SMILES notation, and InChIKey are available on the Chemical Properties tab above.
Yes. Every batch of DSIP is independently tested by Janssen Analytical Laboratories (ISO 17025-accredited). Testing includes HPLC purity analysis, mass spectrometry identity confirmation, LAL kinetic turbidimetric endotoxin assay, and USP <71> sterility testing. Full results are provided in the batch-specific COA. Additional documentation is available on the COA/HPLC/MS and 3rd Party Testing tabs above.
Orders placed before 2:00 PM EST ship same day via cold-chain logistics with gel ice packs to maintain product integrity during transit. Most domestic orders arrive within 2-4 business days. Full tracking is provided. All vials are sealed under inert atmosphere and packaged to prevent damage.
Yes. Tiered pricing is applied automatically at checkout: 2+ units at 10% off, 3+ units at 15% off, and 5+ units at 20% off. For institutional or bulk research inquiries (10+ vials), contact us at contact@aureumpeptides.com for custom pricing.
Compatibility depends on your specific experimental design. DSIP is provided as a single-compound lyophilized preparation for maximum flexibility. When using multiple compounds, reconstitute each separately and add to experimental systems independently to avoid potential interactions during reconstitution. Check the "Researchers Also Purchased" section below for commonly paired research compounds.
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