5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy metabolism. NNMT catalyzes the methylation of nicotinamide using SAM as a methyl donor, and its inhibition has been studied in the context of metabolic regulation and adipocyte biology.
Biochemical Characteristics
Specifications
Molecular Formula
C11H13NO
Molecular Weight
175.23 g/mol
CAS Number
42780-81-8
5-Amino-1MQ has a molecular weight of 175.23 g/mol and is a quinolinium-based small molecule, not a peptide. It functions as a competitive inhibitor of NNMT by occupying the nicotinamide binding pocket.
NNMT is highly expressed in adipose tissue and its inhibition has been associated with increased intracellular NAD+ and SAM levels in preclinical models.
Research Applications
Metabolic research: Studies examining NNMT inhibition effects on adipocyte differentiation and lipid accumulation.
NAD+ biology: Research on NNMT as a regulator of intracellular NAD+ pools.
Obesity models: Preclinical studies in diet-induced obesity mouse models.
SAM cycle: Studies on methyl donor metabolism.
Preclinical Research
Neelakantan et al. (2018) demonstrated that NNMT inhibition with 5-Amino-1MQ reduced body weight and white adipose tissue mass in diet-induced obese mice without affecting food intake.
Article Author
DS
Article Author
Dr. Sarah Chen, Ph.D.
Biochemistry researcher specializing in small molecule pharmacology.
This content was prepared for informational purposes based on published preclinical research.
Citations
1
Neelakantan H, et al. "Selective and membrane-permeable small molecule inhibitors of NNMT reverse high fat diet-induced obesity in mice." Biochem Pharmacol. 2018;147:141-52. PubMed
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24 months powder at -20°C
6 months DMSO stock at -20°C
Handling
Dissolve in DMSO for stock solution.
Aliquot to avoid freeze-thaw.
Limit DMSO to <0.1% in aqueous assays.
Frequently Asked Questions
5-amino-1MQ is verified at ≥99.0% purity via reverse-phase HPLC analysis. Each batch also undergoes ESI mass spectrometry for identity confirmation, LAL endotoxin testing (<0.1 EU/mg), and USP <71> sterility testing. A batch-specific Certificate of Analysis (COA) is included with every order.
Add bacteriostatic water (0.9% benzyl alcohol) slowly to the vial wall. Gently swirl to dissolve — do not shake or vortex. Reconstituted peptide should be stored at 2-8°C and used within 30 days. For single-use applications, sterile water may be substituted (no preservative, use immediately).
Lyophilized (powder): Store at -20°C, protected from light and moisture. Shelf life: 24 months. Reconstituted (solution): Store at 2-8°C, use within 30 days. Critical: Allow the vial to reach room temperature before opening to prevent moisture condensation inside the vial. Avoid repeated freeze-thaw cycles (max 3 recommended).
The CAS registry number for 5-amino-1MQ is 42780-81-8. Molecular weight: 175.23 g/mol. Molecular formula: C11H13NO. Full chemical characterization data including PubChem identifiers, SMILES notation, and InChIKey are available on the Chemical Properties tab above.
Yes. Every batch of 5-amino-1MQ is independently tested by Janssen Analytical Laboratories (ISO 17025-accredited). Testing includes HPLC purity analysis, mass spectrometry identity confirmation, LAL kinetic turbidimetric endotoxin assay, and USP <71> sterility testing. Full results are provided in the batch-specific COA. Additional documentation is available on the COA/HPLC/MS and 3rd Party Testing tabs above.
Orders placed before 2:00 PM EST ship same day via cold-chain logistics with gel ice packs to maintain product integrity during transit. Most domestic orders arrive within 2-4 business days. Full tracking is provided. All vials are sealed under inert atmosphere and packaged to prevent damage.
Yes. Tiered pricing is applied automatically at checkout: 2+ units at 10% off, 3+ units at 15% off, and 5+ units at 20% off. For institutional or bulk research inquiries (10+ vials), contact us at contact@aureumpeptides.com for custom pricing.
Compatibility depends on your specific experimental design. 5-amino-1MQ is provided as a single-compound lyophilized preparation for maximum flexibility. When using multiple compounds, reconstitute each separately and add to experimental systems independently to avoid potential interactions during reconstitution. Check the "Researchers Also Purchased" section below for commonly paired research compounds.
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